In a small coal-mining town nestled in the Appalachian Mountains, Ave Maria Mulligan, a self-proclaimed spinster at 40, leads a predictable life managing her late father's pharmacy. As the town's unofficial historian, Ave enjoys a quiet existence until an unexpected discovery about her family's past shatters her routine. This revelation sends her on a journey to understand her true heritage, prompting a series of personal and emotional transformations. With the quirky support of her tight-knit group of friends and townsfolk, she begins to reevaluate her relationships and future goals.

Amidst the atmosphere of Appalachia, where everyone knows each other's secrets, Ave navigates her evolving identity while grappling with romantic entanglements and societal expectations. The arrival of Jack MacChesney, a charming coal miner who harbors feelings for Ave, further complicates her already tumultuous journey. As she embarks on this path of self-discovery, Ave faces numerous challenges and heartwarming revelations that test her resilience and redefine what family and love truly mean in the fabric of their unique community.