Rose Lorkowski, a former high school cheerleader, is now a single mother to her son, Oscar. Struggling to make ends meet with her low-income job as a maid, she learns that Oscar has been expelled from his school due to his behavioral issues. Seeking better opportunities and a stable home environment, Rose turns to her lover, Mac, a married police officer, for advice. He suggests she can earn much more money cleaning crime scenes. Eager for a fresh start, Rose recruits her unreliable sister Norah and starts a business specializing in the clean-up of biohazardous situations.

The sisters’ new venture brings them face-to-face with death and tragedy, offering them a new perspective on their own personal struggles. Their work in the cleaning business becomes a turning point in their lives, challenging them to resolve past conflicts and family issues. Meanwhile, their out-of-work father Joe looks after Oscar and gets involved in one of his countless dubious business schemes. As they face numerous hurdles in their entrepreneurial journey, Rose and Norah discover the importance of family and learn what it means to truly support each other in times of need.