At a Florida railway station, baggage clerks Chick and Wilbur are tasked with delivering crates to McDougal's House of Horrors wax museum. Unbeknownst to the bumbling duo, the crates contain the actual bodies of Count Dracula and Frankenstein's monster, who are very much alive. Dracula plans to revive the monster with a new brain that can be easily controlled, pinpointing Wilbur's simple and impressionable mind as the perfect candidate. As Chick and Wilbur deliver the crates, the creatures escape, causing McDougal to accuse the clerks of theft and involving the insurance company, which sends an investigator, Joan, undercover to recover the 'stolen' exhibits.

Joan's interest in Wilbur isn't purely professional; she is, in fact, working with Dracula under the pretense of love to secure Wilbur for the brain replacement. Meanwhile, Wilbur's actual girlfriend, Sandra, also secretly in cahoots with Dracula, tries to persuade Wilbur to undergo an operation, supposedly for his health. As the full moon rises, Lawrence Talbot arrives from London, seeking to warn the duo about Dracula's intentions and prevent the monster's revival. Talbot himself harbors a terrifying secret that becomes increasingly difficult to hide as night falls. Circumstances throw the group together at McDougal's House of Horrors, where the real horror begins as the creatures come face-to-face with the unsuspecting clerks.