In a dystopian future where the world's most notorious criminals compete in brutal car races for their freedom, Frankenstein, a legendary masked driver, is pitted against the new global setting of the Death Race in South Africa. Carl Lucas, with his alter ego as Frankenstein, is just one race away from earning his release from the maximum-security prison. But the stakes are higher than ever as he faces a powerful opponent in Niles York, a ruthless businessman who takes control of the Death Race and relocates it to the desert. Adding to the challenge, Lucas must also deal with his shifting relationships with his loyal pit crew, which includes Goldberg, Lists, and his navigator Katrina, who continue to support and strategize with him.

As the race kicks off, Lucas and his crew confront increasingly dangerous obstacles and rival drivers, all equipped with heavily armed vehicles. The deadly environment intensifies as York manipulates the race to ensure it’s more lethal and spectacular, drawing in huge profits and higher viewership. Lucas must maneuver through treacherous terrains and relentless attacks while grappling with his internal struggles and the external threats posed by York's machinations. The film builds tension and showcases high-octane action as Lucas's journey through the perilous race unfolds, pushing him to the limits of his endurance and skill.