Duane Bradley and his once-conjoined twin, Belial, are back for another bizarre adventure. They journey with Granny Ruth and her band of deformed individuals to a safe haven in the countryside, where they aim to take a respite from their tumultuous lives. Granny Ruth, the matriarch and caretaker of this peculiar family, is poised to support Belial's partner, Eve, who is about to give birth to their offspring. The group is hopeful for a peaceful process, but the anticipation of Eve's labor coupled with Duane's increasingly unstable behavior creates a tense atmosphere.

As Duane grapples with his mental state and troubled relationship with Belial, the outside world once again imposes threats on their fragile sanctuary. Law enforcement and local citizens become entangled in their lives, leading to a series of confrontations rife with chaos and violence. As tensions rise, secrets unfold, and bonds are tested within the eerie household, culminating in an escalating struggle for survival. The narrative dives deep into the intricacies of kinship and monstrosity, exploring themes of loyalty and identity amid the growing mayhem.