In this family comedy, a pampered Chihuahua from Beverly Hills named Chloe finds herself accidentally left behind in Mexico by her wealthy owner, Vivian. Chloe, who has lived a sheltered and luxurious life, is completely unprepared for the harsh realities outside her golden life. Alone and afraid, she is soon kidnapped by a group of unscrupulous dog fighters. Her only hope for survival comes in the form of Delgado, a jaded former police dog with his own personal demons, who reluctantly decides to protect her on her journey. As Chloe tries to navigate her way back home, she begins to learn the value of friendship and discover her own inner strength.

Meanwhile, Papi, a fun-loving Chihuahua who is madly in love with Chloe, learns of her peril. Despite his small size and the danger ahead, he embarks on a daring mission across the border to find her. Along the way, Papi is joined by a diverse group of animals, each offering their unique skills to aid in the rescue. This motley crew of unlikely heroes faces various challenges, bonding over their shared goal. Through this adventure, Chloe and Papi, along with their new friends, learn important lessons about love, courage, and the importance of staying true to oneself, setting the stage for a heartfelt and adventurous journey.