After being captured and placed in a comatose state for twelve years, Selene wakes up in a world where humans have discovered the existence of both Vampire and Lycan clans, sparking a fierce and brutal campaign to eradicate both immortal species. As she navigates this new reality, Selene discovers that during her imprisonment, scientists have taken her daughter, Eve, born from her union with Michael Corvin, integrating both Vampire and Lycan genes. Eve possesses unique and powerful abilities, making her a target for those seeking to exploit the immortals. Selene must now fight to protect her daughter and unravel the conspiracy against their kind.

As Selene battles both humans and Lycans, she uncovers a plot by the Lycans to create a new strain of super Lycans, immune to the traditional weaknesses of their race. With the help of David, a Vampire ally, and Detective Sebastian, a sympathetic human, she confronts the challenges posed by the new Lycan leader. Amidst this turmoil, Selene's primary objective remains the safety of her daughter, who is pivotal to the future of Vampires and Lycans alike.