In the first segment of this double-feature homage to exploitation B-movies, a deadly virus outbreak occurs in a rural Texas town, leading to a gruesome, zombified catastrophe. A group of survivors, including a go-go dancer with a unique prosthetic limb, her tough-as-nails sister, and a few locals must band together to fend off hordes of the infected. The narrative follows their chaotic fight for survival, as they encounter various eccentric characters including an enigmatic BBQ joint owner with a questionable menu and military forces with their own agenda. The gritty visuals and gore are interspersed with intentional scratches and missing frames that evoke the era of 1970s grindhouse cinema.

The second story shifts gears to a high-octane thriller involving a scar-faced, psychopathic stunt driver known for his deadly hobby of preying on young women with his "death-proof" car. This sadistic game takes a turn when the stuntman sets his sights on a new group of women, including a spunky radio DJ and her friends. What begins as a leisurely ride in the stuntman's muscle car becomes a nightmarish game of cat and mouse on the desolate highways. The women must use their wits and determination to outmaneuver their pursuer, resulting in high-speed chases and heart-thumping stunts that keep the adrenaline pumping and the stakes escalating until the mid-point revelation.