Two Miami narcotics detectives, Mike Lowrey and Marcus Burnett, find themselves in the midst of a high-stakes investigation when ecstasy floods into the city. The duo discovers that the drugs are connected to a dangerous Cuban drug cartel, leading them to undercover probe the operation. Their unique, albeit chaotic, partnership is put to test as they navigate through the violent world of drug trafficking. Despite their differing styles – Mike's playboy attitude and Marcus's family-man demeanor – they must rely on their unbreakable bond to dismantle the cartel's network.

As the investigation deepens, the situation becomes personal when Syd, Marcus's sister, is revealed to be an undercover agent for the DEA, working to infiltrate the same criminal empire the detectives are targeting. Unbeknownst to her brother, Syd's involvement not only endangers her life but unknowingly creates tension between the two partners. The detectives must navigate through a minefield of professional challenges and personal dilemmas, as they race against time to save Syd, bring down the cartel, and stem the tide of narcotics flooding their city.