Captain Jack Sparrow finds his luck running dry as his past catches up with him when deadly ghost sailors, led by his old nemesis, the terrifying Captain Salazar, escape from the Devil's Triangle, bent on killing every pirate at sea, particularly Jack. Salazar's crew, the undead Silent Mary, is an unstoppable force of nature on the seas, leaving a path of destruction in their wake. Jack's only hope of survival lies in the legendary Trident of Poseidon, a powerful artifact that bestows upon its possessor total control over the seas. To find it, Jack must forge an uneasy alliance with Carina Smyth, a brilliant and beautiful astronomer, and Henry, a headstrong young sailor in the Royal Navy.

Together, the unlikely trio embarks on a perilous adventure to find the trident. En route, they must contend with a host of challenges, including the deceptive tides of the supernatural triangle, the perils of the open sea, and the wrath of Salazar's relentless pursuit. Henry has his own personal reasons for wanting to track down the Trident, which may complicate their mission. Meanwhile, Jack is desperate to reverse his recent spate of ill fortune and save the dwindling freedom of the pirate way of life, but he can't shake the feeling that his legendary luck has finally run out.