In the heart of New York City, the guests of the sleazy Hotel Quickie are experiencing something beyond the ordinary. When a number of bizarre incidents begin to occur, involving male guests at the hotel being attacked during intimate moments, the hotel quickly garners a terrifying reputation. The attacks are vicious and unusual, as the victims are found with their private parts brutally mutilated. Amidst the scandal and horror, the city becomes gripped with fear, with rumors circulating about a bizarre and malevolent entity responsible for the inexplicable happenings.

Detective Luigi Mackeroni is assigned to investigate the bizarre cases. With an air of skepticism initially, the grizzled, gay detective begins to uncover the shocking truth behind the assaults. His sleuthing leads him to a jaw-dropping discovery: the assailant is not a person but a creature, genetically altered and specifically designed. It's revealed to be a bloodthirsty condom, seemingly with a life and lethal will of its own. As Mackeroni delves deeper into this peculiar case, his personal involvement grows, entangling his professional duty with his life's unexpected twists. The detective is drawn into an underworld of grotesque experimentation and sinister motives, where science has gone awry, and the line between pleasure and pain is dangerously blurred.