Ten years after the events of the first outbreak, the makeshift family of zombie apocalypse survivors - Tallahassee, Columbus, Wichita, and Little Rock - continue to navigate the ever-evolving landscape of Zombieland. Their journey brings them to the ironically named sanctuary of the White House, where they settle into a semblance of domestic normalcy. However, their peace is short-lived, as interpersonal tensions and the desire for something more than survival spark discord within the group. Columbus and Wichita's relationship faces strain, while Little Rock yearns for independence and a connection with people her own age.

The emergence of new human survivors and evolved zombies add complications to their lives. The group encounters pockets of other survivors, including the effervescent and somewhat dimwitted Madison, and the tough-as-nails Nevada, who mirror the group's dynamics in their unique ways. Meanwhile, the undead have developed into different strains, posing greater threats than before. One strain, nicknamed "T-800s," possesses a near-indestructible nature, challenging the seasoned effectiveness of the group's zombie-slaying methods. The evolving landscape and the new challenges it brings tests the strength and adaptability of their chosen family as they confront internal and external dangers in a world that constantly remains one step ahead of their comfort zone.