In the midst of a devastating epidemic that threatens the children of Manhattan, Dr. Susan Tyler, an entomologist, creates a genetically engineered insect to combat the disease-carrying cockroaches. The new species, named the Judas breed, is designed to die off after a single generation. Initially, the experiment appears successful, and the disease is eradicated. However, three years later, alarming signs emerge that the Judas breed has not only survived but evolved, developing the ability to mimic their human predators.

As mysterious deaths begin to surface, Dr. Tyler, accompanied by her husband Peter Mann, a CDC agent, and a small team, delves into the dark labyrinths underneath the city. They discover that the Judas breed has grown larger and more intelligent, posing a new, unforeseen threat to humanity. The team races against time to uncover the extent of the infestation and find a way to eliminate the creatures before they spread unchecked. Tensions rise as they navigate through the perilous underground realm, facing the terrifying realization that the line between predator and prey has dangerously blurred.