Alice Parker arrives in the Amazon jungle searching for her fiancé, Jerry Russell, who has gone missing while exploring the region. She enlists the help of Rio Galdez, a seasoned guide who is familiar with the treacherous terrain and the indigenous Jivaro tribe. Despite initial resistance and skepticism from Rio, who warns Alice about the dangers and the violent nature of the Jivaro people, she remains determined to find Jerry. Rio introduces Alice to an eclectic group of adventurers and workers in the jungle settlement, including Tony, a rough-and-ready prospector, and other explorers who add to the perilous atmosphere.

As they set out on their journey deep into the jungle, Alice and Rio face multiple challenges ranging from harsh environmental conditions and wild animals to hostile encounters with the Jivaro tribe. The tension between Alice's unwavering determination and Rio's practical experience creates a dynamic relationship that drives the expedition forward. With each step closer to finding Jerry, they unravel mysteries and face tests of survival that strain their resolve and courage. Along the way, they learn about trust, resilience, and the haunting lure of the unknown wilderness, culminating in critical discoveries that shed light on Jerry's fate.