In a distant future, a medical rescue spaceship called Nightingale 229 receives a distress signal from a remote mining colony. The crew, led by Captain A.J. Marley, includes co-pilot Nick Vanzant, medical officer Dr. Kaela Evers, and paramedic Yerzy Penalosa among others. Responding to the call, they engage their dimensional jump drive to reach the source of the signal, but the jump goes awry, causing damage to their ship. They manage to arrive at the mining colony and encounter Karl Larson, the lone survivor who claims his crew was wiped out in a mining accident.

As the Nightingale crew investigates, they discover Karl has scavenged a mysterious alien artifact from the mining site. Almost instantly, strange occurrences and transformations begin affecting both the survivor and the crew members, setting off a chain of increasingly perilous events. As internal dynamics become strained and danger mounts, the rescue mission turns into a desperate struggle for survival against an unknown and evolving threat.