A hedonistic adventurer named Frank obtains an ancient puzzle box, which is said to be a portal to another dimension filled with unimaginable pleasures. Upon solving the puzzle, Frank is transported to a world of pain and torment at the hands of the Cenobites, a group of sadomasochistic entities that blend the lines between pleasure and pain. Frank is torn to pieces, and the Cenobites take him away, leaving the box behind in the human world.

Some time later, Frank's brother Larry moves into the long-abandoned family home with his second wife, Julia, who is harboring a dark secret involving a past affair with Frank. An accidental spill of blood in the house resurrects Frank in a gruesome, incomplete form. Desperate to regain his full humanity, Frank convinces Julia, still infatuated with him, to lure men back to the house where he can use their blood to restore himself. Their dark deeds begin, attracting the attention of Larry's daughter, Kirsty, who becomes suspicious of her stepmother's actions.