Two notorious criminals, Seth and Richie Gecko, are on the run after a series of violent crimes. They kidnap a former preacher named Jacob Fuller and his two children, Kate and Scott, using their RV to cross the border into Mexico. Their plan is to rendezvous with a contact at a remote strip club called the Titty Twister and lay low until it's safe to proceed. The Gecko brothers use intimidation and violence to keep the Fuller family compliant, hiding their true violent nature behind a veneer of desperation and urgency. Tensions between the siblings and their captives simmer, with Seth trying to maintain control while Richie’s increasingly erratic behavior threatens to unravel their plans.

Upon arriving at the Titty Twister, the group soon discovers that the establishment is more than it appears. The night descends into chaos as they find themselves fighting for their lives against the club’s bloodthirsty inhabitants. The criminals and the hostages must band together to survive the night. The dynamic of power and desperation shifts as the human characters face a new, unforeseen horror, testing their resolve and forcing them to confront their own morality and instincts for self-preservation amidst escalating violence.