Struggling single mother Callie relocates her two children, teenager Trevor and science-savvy Phoebe, to a dilapidated farmhouse in Summerville, Oklahoma, bequeathed to them by her estranged father, the late Dr. Egon Spengler. The small town is far removed from the bustling life they've known, offering little excitement or promise. But as they settle into their inherited home, the kids begin to uncover relics and hints of their grandfather's secret past, which reveal his legacy as a Ghostbuster. Phoebe discovers a mysterious underground laboratory filled with ghost-hunting equipment, while Trevor stumbles upon the iconic Ghostbusters vehicle, Ecto-1.

Phoebe's curious nature and scientific mind lead her to befriend her summer school teacher, Gary Grooberson, who shares her fascination with seismology, especially since the town, devoid of any fault lines, has been mysteriously experiencing unexplained earthquakes. As Phoebe and Trevor delve deeper into their grandfather’s artifacts and experiments, they encounter supernatural occurrences that hit close to home. Their discoveries awaken the town's dormant ghosts, presenting the children with both a link to their family's history and a call to action. They must embrace their legacy and rally their newfound allies to confront the spectral phenomena that threaten Summerville, and perhaps the world, showing them that they are more connected to the original Ghostbusters than they ever imagined.