Eddie Brock, now struggling with his dual life as a journalist and host to the alien symbiote Venom, faces new threats as a mysterious organization hunts for the powerful entity residing within him. The organization believes that harnessing the symbiote's abilities could provide unprecedented power and is relentless in its pursuit. Meanwhile, Eddie is contacted by a scientist named Dr. Adrian Chase, who claims to have knowledge of the symbiote's origins and seeks to help him. Eddie, despite his reluctance, agrees to meet Chase after Venom senses hidden intentions and threats around them. As they delve deeper into their investigation, they discover experiments blending human and symbiote DNA, which could destabilize the natural order if successful.

Amidst growing danger, Eddie must navigate complex alliances and face foes with powers to rival Venom's own. The lines between ally and enemy blur as Eddie and Dr. Chase uncover a conspiracy that threatens to unleash chaos on a global scale. The stakes grow higher when Eddie realizes that someone from his past is deeply involved in the organization's schemes. As tensions escalate, Eddie grapples with his inner demons, trying to reconcile his sense of self with Venom’s more primal instincts. With time running out and countless lives at risk, Eddie must decide how far he is willing to go to protect people from an imminent catastrophe, while Venom’s presence pushes him towards embracing a darker path.