George Simmons, a successful comedian and movie star, learns he has a terminal illness and struggles with the reality of his condition. Feeling lost and isolated, he decides to return to his roots and perform stand-up comedy again. During one of his gigs, he meets Ira Wright, an aspiring comedian stuck in a mundane job, and sees potential in him. George hires Ira as his joke writer and personal assistant, forming a bond that oscillates between mentorship and friendship. As Ira becomes involved in George's world, he begins to grapple with his own ambitions, ethics, and the cost of fame.

The two men navigate the complex world of stand-up comedy and personal relationships, dealing with issues of success, authenticity, and emotional vulnerability. George also reconnects with Laura, the love of his life, who is now married with children. He contemplates what could have been, longing for a second chance. Meanwhile, Ira's association with George propels him closer to the comedy career he dreams of, but this progress tests his integrity and true desires. As both men confront their pasts and futures, they learn valuable lessons about life, mortality, and the true essence of happiness.