After narrowly escaping death in an explosive mine shaft trap, the seemingly invincible Michael Myers is presumed dead but once again survives. He finds refuge with a reclusive hermit for a year, recuperating until the arrival of Halloween prompts him to return to his murderous ways. His primary target is his young niece, Jamie Lloyd, who has been left traumatized after their last encounter and is now residing in a children’s hospital. Possessing a telepathic connection with her uncle, Jamie experiences nightmarish visions of Michael’s return and his continuing thirst for vengeance against her and the residents of Haddonfield.

Halloween approaches, and with it the mounting terror of Michael’s anticipated killing spree. Dr. Sam Loomis, the obsessed and determined psychiatrist, continues his quest to stop Michael once and for all. Joining forces with the local sheriff, they attempt to protect Jamie and the town from the impending bloodshed. As Michael slashes his way through the townsfolk, leaving a trail of chaos in his wake, Jamie’s connection to him becomes both a curse and the key to ending the nightmare. The police and Dr. Loomis use her link to anticipate Michael’s moves, culminating in a showdown that once again tests the limits of evil’s endurance.