George Washington McLintock is a wealthy, influential cattle baron who presides over his vast ranch with a firm but fair hand. Despite his success, he faces several personal and professional challenges. His estranged wife, Katherine, unexpectedly returns after two years, seeking a divorce and bringing tension with her. Katherine’s sophisticated demeanor starkly contrasts with the rugged, rough-and-tumble life of the ranch, leading to a series of humorous and contentious interactions. Meanwhile, McLintock must also deal with the problems arising from government policy changes that threaten his business and relationships with local Native American tribes.

Complications escalate with the arrival of their daughter, Becky, and a potential suitor, Devlin Warren, who adds to the mix of emotions and misunderstandings. There are also disputes with corrupt land agents and other ranchers vying for power. Through a series of comedic and sometimes chaotic encounters, McLintock, Katherine, and other characters confront their differences and learn valuable lessons about love, loyalty, and respect. The story intertwines themes of family dynamics, social issues, and the struggle to maintain harmony in a rapidly changing world, setting the stage for realization and reconciliation.