Romy and Michele, two inseparable best friends living in Los Angeles, lead relatively carefree lives, but feel inadequate when they learn about their upcoming ten-year high school reunion. To impress their former classmates, they decide to reinvent themselves by fabricating successful careers. Upon failing to find real jobs that fit their grandiose visions, they claim to be the inventors of Post-it Notes. Full of confidence and armed with their made-up success stories, they head back to their hometown in Tucson, Arizona.

Once at the reunion, Romy and Michele are confronted by long-standing insecurities and unresolved issues stemming from their high school days, especially with the popular clique that made their teenage years difficult. As old dynamics resurface, the pair must navigate through the pretenses they've built and face the reality of who they truly are. The event becomes a catalyst for self-discovery and challenges their friendship, pushing them to realize that authenticity and mutual support are far more valuable than societal approval.