Excommunicated and on the run after the events of the previous installment, the titular assassin finds himself with a $14 million bounty on his head, making him the target of hitmen and women everywhere. With an hour's grace period before the contract goes into effect, he uses every second to prepare for the onslaught. He navigates through New York City, seeking aid to escape the city and find a way to survive. However, his past affiliations have been severed, and old friends are either unable or unwilling to help, given the immense pressure from the powerful High Table, the council of high-level crime lords that enforces the assassin's coded rules.

Forced to draw upon contacts even more dangerous than the ones he's fleeing from, he seeks out a figure from his past who owes him a favor. Together, they embark on a perilous journey that takes them to the ancient and secretive world of the world's deadliest killers. With the bounty on his head growing ever larger, alliances are tested, and old enemies become reluctant allies. As he fights against some of the most skilled assassins in the world, he is driven to the edge of his physical and emotional limits, setting the stage for a relentless battle for survival against impossible odds.