In the gritty backdrop of New York City's East Village, a group of impoverished artists struggle to survive and create under the shadow of HIV/AIDS, addiction, and gentrification at the dawn of the 1990s. Mark, an aspiring filmmaker, and his roommate Roger, a musician who is HIV positive, face eviction from their rundown apartment, setting the stage for a year in the life of a tight-knit circle of friends. The narrative intricately weaves their stories of love, loss, and the relentless pursuit of their dreams, all while grappling with the looming threat of their rent increasing, which could displace them from the only home they know.

As the year unfolds, new relationships blossom, and existing ones are tested. Mimi, a dancer with a drug addiction, captures Roger's heart, further complicating his struggle with his health and aspirations. Meanwhile, Tom Collins, a philosopher and former professor, finds love in an unexpected place, challenging his own fears and societal prejudices. Maureen, a performance artist, and Joanne, a lawyer, navigate the complexities of their relationship amidst their differing lifestyles and ambitions. Together, these characters confront their personal demons and societal challenges, seeking solace in their art and each other, illustrating the profound impact of friendship and creativity in the face of adversity.