A group of wealthy trophy hunters, led by a ruthless business tycoon, genetically engineer Graboids to be more deadly and hunt them on a tropical island. When the creatures inevitably escape and begin to breed uncontrollably, wreaking havoc on the environment, a team of scientists and survivalists, including biologists Jasmine Welker and Jimmy, realize that they are in over their heads. Desperate for help, they track down survivalist and Graboid expert Burt Gummer, who is living in isolation.

Burt reluctantly agrees to join the mission but quickly realizes that the Shrieker evolution of the Graboids poses a new level of danger. Alongside Jimmy and the rest of the makeshift team, Burt races against time to develop a plan to contain the threat before the Shriekers overrun the island. The group faces a series of escalating challenges as they battle both the monstrous creatures and their own fears, learning to adapt and trust each other in order to survive. Their efforts culminate in a high-stakes showdown that tests their resolve and ingenuity, leaving them forever changed by their harrowing adventure.