While driving through the backwoods of West Virginia, medical student Chris Flynn finds his route blocked by a chemical spill. He opts for a dirt road detour and quickly encounters a group of five friends whose car is disabled by barbed wire placed deliberately on the road. The group includes Jessie, Carly, Scott, Evan, and Francine. As they search for help, they stumble upon a secluded cabin filled with grotesque hunting trophies and human remains.

Realizing they're being hunted by a family of deformed, inbred cannibals, the group frantically attempts to escape the deadly woods. The friends are forced to navigate the treacherous terrain, using their wits and courage to survive against the relentless pursuit of their sadistic attackers. They face a series of harrowing challenges and shocking discoveries that test their limits, revealing the true horrors lurking in the forest.