In present-day Iraq, Nick Morton, a roguish treasure hunter and soldier, stumbles upon the ancient tomb of Princess Ahmanet, a powerful Egyptian princess who was entombed alive. Nick's discovery is not a typical archeological find; Ahmanet was buried far from Egypt, her home, as punishment for unspeakable crimes. When Ahmanet's sarcophagus is airlifted out of the desert, Nick is plagued by disturbing visions, a sign of the malevolent curse that is beginning to unfold. Ignoring warnings from a British Egyptologist, Jenny Halsey, Nick inadvertently frees Ahmanet from her earthly prison, setting off a series of supernatural events.

With Ahmanet released, her terrifying powers begin to regenerate, and she embarks on a vengeful quest to reclaim her destiny that was unjustly taken from her thousands of years ago. While London becomes the stage for Ahmanet's wrath, Nick is caught in a battle for his soul. As chaos unfolds, Nick must confront the horror of Ahmanet's curse, which seeks to consume and transform him as part of her larger, sinister plan. Meanwhile, a shadowy organization with their own interest in Ahmanet's resurrection observes and manipulates from the sidelines, hinting at a wider world of monsters and the supernatural.