A daring and resourceful American named Frank Chandler, trained in the mystical arts, adopts the secret identity of a magician known as Chandu. Equipped with hypnotic abilities and other mystical skills learned in an Egyptian temple, Chandu sets out to combat the nefarious schemes of an evil scientist named Roxor. Roxor has devised a terrifying death ray that he plans to use to seize control of the world. Chandu's mission is personal as well as noble; he must rescue his friend and fellow magician, Robert Regent, who has been captured by Roxor.

Chandu's journey takes him across exotic locales and leads to encounters with various dangers and deceptions. He uses his powers to unravel Roxor's plots and protect innocent lives. Along the way, Chandu also struggles to keep his sister Dorothy and her two children safe from harm, as they unwittingly become entangled in his battle against Roxor. A thrilling cat-and-mouse game ensues, filled with mysticism, suspense, and adventure, as Chandu races against time to thwart Roxor's plans and save his loved ones.