The film explores the life and career of British artist Ralph Steadman, known for his distinctive, chaotic style and his collaborations with American writer Hunter S. Thompson. Johnny Depp visits Steadman's studio, acting as a narrator and guide, to delve into Steadman's world. The documentary presents Steadman's artistic process, illustrating how he produces his provocative illustrations that often critique society and politics. Through interviews, animations, and archival footage, the film portrays Steadman's influences and his passionate engagement with the counterculture movement of the 1960s and 70s.

The narrative weaves through various phases of Steadman's career, highlighting his relationship with Thompson and their creation of Gonzo journalism. It reveals the interplay between their personalities and artistic visions, shedding light on the tumultuous yet productive nature of their partnership. As the film progresses, it captures Steadman’s reflections on his work, providing insights into his motivations and the impact of his art. The documentary culminates in a deeper understanding of Steadman’s legacy, emphasizing his role in shaping modern illustration and his unwavering commitment to challenging the status quo through art.