In 1973 Los Angeles, widowed social worker Anna Tate-Garcia investigates the case of Patricia Alvarez, whose two children are found locked in a closet. Ignoring Patricia's warnings about a malevolent spirit, Anna temporarily places the children in protective custody. That night, a supernatural entity attacks the boys and they are found drowned. Soon after, Anna's children, Chris and Samantha, begin experiencing eerie occurrences at their home, amplifying Anna's fears. Seeking answers, she discovers that the spirit haunting her family is La Llorona, a ghost who preys on children.

Anna reaches out to Father Perez, who connects her to former priest Rafael Olvera, now a curandero working to fight malevolent forces. Rafael educates Anna about La Llorona's curse and attempts to ward off the spirit using various spiritual tactics and traditional methods. The battle against La Llorona becomes increasingly perilous as the relentless entity targets Anna's family with escalating attacks.