Ex-cop Frank Castle's life is shattered when his family is brutally murdered by the underworld after he leads a successful undercover operation. Consumed by a vendetta and presumed dead by the world at large, Castle emerges as a vigilante, adopting the skull symbol to terrorize the criminal element responsible for his family's death. Operating from the sewers, he becomes a relentless one-man jury and executioner. Known by the public as "The Punisher," his mission is clear: fight crime by any means necessary, aiming to dismantle the mafia that plagues the city.

The Punisher's war on crime escalates, leading to an inevitable clash with the syndicates' bosses, who have become increasingly worried about his impact on their operations. Meanwhile, his former police partner, now a detective, tirelessly follows the trail of carnage, hoping to track down and bring to justice the person he believes is an ex-colleague turned vigilante. Simultaneously, the mobsters, desperate to stop their unseen nemesis, enlist the help of the Yakuza, the Japanese mafia. As The Punisher cuts a swath through both Italian and Japanese mob ranks with his unique brand of justice, the stage is set for a deadly confrontation that will determine the fate of the city's criminal underworld.