Bernadette Fox is an agoraphobic architect who has become notorious in her Seattle community for her odd behavior and disputes with neighbors. Her life largely revolves around her supportive husband, Elgie, a successful tech expert, and their bright teenage daughter, Bee. When Bee requests a family trip to Antarctica as a reward for her excellent grades, Bernadette becomes increasingly anxious and chaotic, overwhelmed by the societal expectations around her. Amidst planning the trip, Bernadette's past traumas and brilliant, yet unrecognized, architectural career slowly come to light, shedding insight into her reclusive and eccentric nature.

As Bernadette's mental state deteriorates, she begins to rely on a virtual assistant for mundane tasks, which unwittingly exposes their private life to Elgie's colleague and the FBI. The situation spirals out of control when a series of misunderstandings and interventions force Bernadette into a state of flight. This catalyst sets the entire family on an unexpected journey of self-discovery and reconciliation, challenging each member to confront their own personal truths while searching for Bernadette who has seemingly disappeared.