Pat Kramer, an ordinary suburban housewife, becomes an unwitting test subject after exposure to a combination of household chemicals and products from her husband's advertising firm. Gradually and inexplicably, Pat starts shrinking in size. Her condition becomes a media sensation, and she is both celebrated and pitied as she continues to diminish. As Pat becomes smaller, she experiences an array of challenges in her daily life, struggling with both physical obstacles and the strain on her relationships with her family.

Despite attempts by the scientific community and her friends to understand and reverse her shrinking, Pat's condition worsens. She is eventually captured by a group of nefarious individuals who plan to exploit her condition for their own gain. The story follows Pat's journey as she navigates these perils, seeking to regain control of her life while shrinking into obscurity. Her adventures are a mix of comedy and drama, underscoring themes of consumerism, feminism, and human resilience.