Dr. Elgin Clark, a rancher plagued by a rabbit infestation devastating his crops, recruits the help of scientists Roy and Gerry Bennett in a desperate bid to control the population. The Bennetts propose an experimental serum meant to disrupt the rabbits' breeding cycle. However, a test subject escapes before the process is complete, mating with wild rabbits and inadvertently creating a new breed of giant, carnivorous creatures. These monstrous rabbits quickly begin terrorizing the local community, leaving a trail of destruction in their wake.

As the rabid creatures wreak havoc, the town's residents are thrust into a state of panic and chaos. The Bennetts, along with Sheriff Cody and other local authorities, are forced to confront the growing terror head-on. Racing against time, they must find a way to halt the rapidly multiplying giants before the entire region falls victim to the unprecedented horror they're unleashing. The situation becomes increasingly dire as they struggle to develop a plan capable of eliminating the colossal menace confronting them.