Four astronauts, Reed Richards, Sue Storm, Johnny Storm, and Ben Grimm, embark on a space mission, using a spacecraft designed by Reed. The mission's objective is ambitious: to study a cosmic storm and its potential for advancing human knowledge and technology. However, an error in calculations exposes the team to the storm's intense radiation. The aftermath of their encounter with the cosmic forces is beyond their wildest imaginations, fundamentally altering their physical forms and granting them extraordinary abilities. Each member of the team discovers they possess unique powers: Reed can stretch his body into incredible lengths and shapes, Sue can become invisible and generate force fields, Johnny can engulf himself in fire and fly, and Ben transforms into a super-strong, rock-like creature.

As they grapple with their new identities and powers, the team must come together to confront the challenges posed by their transformations. They face public scrutiny, personal dilemmas, and the daunting task of controlling their abilities. A deeper threat emerges when Victor Von Doom, the mission's sponsor and a billionaire industrialist who also underwent exposure to the cosmic storm, experiences a sinister transformation of his own. His ambitions and desire for revenge lead him down a path that pits him against the newly formed team. As tensions rise, the four must overcome their personal conflicts and unite against a common enemy, navigating the complexities of heroism and friendship in a world that is now forever changed.