Quentin "Q" Jacobsen has had a lifelong crush on his enigmatic neighbor, Margo Roth Spiegelman. One night, Margo climbs into Q's bedroom window and enlists his help for a night of revenge against those who have wronged her. They spend the night executing a series of elaborate pranks, strengthening their bond. By morning, Margo swears Q to secrecy regarding their adventure and mysteriously disappears the following day. Q is crushed but intrigued, particularly after he discovers a series of cryptic clues Margo seems to have left behind, leading him to believe she wants him to find her.

Determined to uncover the truth, Q embarks on a road trip with his closest friends, each with their own motivations and expectations. As they piece together Margo's clues, they journey through various towns and meet people who had crossed paths with Margo, learning more about her complex personality. Throughout the quest, Q grapples with his idealized image of Margo versus the reality of who she might truly be. The adventure ultimately becomes as much about self-discovery and growing up as it is about finding the elusive girl he thought he knew.