A genetically engineered assassin, known only as Agent 47, is the culmination of decades of research and 46 earlier Agent clones — boasting unprecedented strength, speed, stamina, and intelligence. His latest target is a mega-corporation that plans to unlock the secret of Agent 47’s past to create an army of killers whose powers surpass even his own. Teaming up with a young woman who may hold the key to overcoming their powerful and clandestine enemies, 47 confronts stunning revelations about his own origins and squares off against his deadliest foe.

During the pursuit, the young woman, Katia, discovers that she has a deeper connection to 47 than she could have ever imagined. As they fight to untangle the mystery of her ancestry, it becomes clear that she is the key to the franchise’s success. With her own extraordinary abilities, Katia joins 47 in a battle against a determined and ruthless adversary — a corporation that will stop at nothing to create an invincible army. As they delve into Katia's past, they also uncover information that leads them towards the truth about the secretive organization responsible for 47's creation.