A renowned neurosurgeon turned Master of the Mystic Arts, Doctor Strange, continues to protect reality from supernatural threats. Still grappling with the consequences of his past choices, Strange is confronted with a new challenge when a young girl named America Chavez arrives in his universe. America possesses a unique ability to travel between different universes but is hunted by a powerful and relentless adversary who seeks to harness her powers for nefarious purposes. Strange enlists the help of his friend and fellow sorcerer Wong, the Sorcerer Supreme, and seeks guidance from the Avenger Wanda Maximoff, better known as the Scarlet Witch.

As Strange and his allies endeavor to protect America from their pursuer, their journey takes them through a myriad of strange and altering realities within the vast multiverse. Each alternative universe presents perilous obstacles and startling revelations, testing the limits of their understanding of reality and magic. With the fabric of the multiverse under threat, Strange must reckon with the true price of the choices he's made, including those related to love and personal sacrifice, while confronting the darkness within himself and the full extent of his power. The mission is fraught with unexpected twists and moral dilemmas, pushing the boundaries of what it means to be a hero.