A scientist in the Philippines inadvertently creates a deadly virus known as "Death One" while attempting to develop a cure for cancer. The virus escapes containment when terrorists steal a sample and one of them is infected. In a desperate attempt to prevent a global pandemic, military forces are deployed, and the infected terrorist is killed. However, his body is disposed of improperly, leading to the virus contaminating the local environment. The result is a disastrous outbreak of reanimated corpses, or zombies, that begin attacking the living.

Meanwhile, a group of vacationing soldiers arrive on the island, unaware of the ongoing crisis. As they explore, they become entangled with a radio DJ and her friends who have also stumbled into the chaos. They quickly realize that the island is overrun by zombies, and struggle to survive while searching for a way to escape the infection and violence. Amid the carnage, they uncover the grim truth about the virus and race against time to find safety.