Deep in the secluded swamps of the American South, a team of scientists led by Dr. Alec Holland works on a secret experiment to combine plant and animal DNA to create a new form of plant life that can thrive in any environment. Their breakthrough has the potential to end world hunger by revolutionizing agriculture. However, their work draws the attention of Anton Arcane, a man consumed by the pursuit of immortality and power. Arcane sends his paramilitary force to seize the formula, believing it holds the key to his desires.

During a surprise attack on the research facility, Dr. Holland is doused with chemicals and set ablaze. Fleeing into the swamp while engulfed in flames, he undergoes a radical transformation. Alice Cable, a government agent assigned to the project, is left behind amidst the chaos. As she navigates the dangers of the swamp to escape Arcane’s mercenaries, she encounters mutated creatures and the altered Dr. Holland, who has become inseparable from the swamp itself. Their paths intertwine as they face the threats lurking in the dense, murky waters of the bayou.