In a bustling Los Angeles, an ordinary day takes a dark turn when a military experiment goes awry, unleashing a monstrous, rapidly growing spider. The scene is set at a local hospital where pest exterminator Alex Mathis is being treated for a minor injury. As chaos erupts from the spider’s escape, Alex finds himself thrust into an unexpected role as the city's unlikely hero. Teaming up with Jose Ramos, a hospital security guard with a big heart and quick humor, Alex uses his expertise to track down the creature wreaking havoc.

As they chase the ever-growing arachnid through the city, the duo faces numerous obstacles and escalating danger, all while city officials scramble to contain the threat before it spreads further. With each encounter proving more treacherous than the last, Alex and Jose must combine their wits and resources to prevent catastrophe. Alongside them, military personnel and scientists race against time to understand the spider’s origins and find a way to stop it before it’s too late. The city’s fate hangs in the balance as the ultimate confrontation between man and beast looms large.