John Rambo has long been fighting battles, but now lives a quiet life on a ranch in Arizona, struggling with old age and haunting memories of his violent past. He's not alone; he has become a father figure to Gabriela, his housekeeper's teenage granddaughter. When Gabriela receives news that could lead her to her estranged father in Mexico, she seeks Rambo's counsel. Despite his warnings of potential danger and heartache, Gabriela defies him and secretly heads to Mexico. Her journey triggers concern when she doesn't return as expected, prompting Rambo to follow her trail.

In Mexico, Rambo uncovers a world of brutality and criminality as he discovers that Gabriela has been kidnapped by a ruthless cartel involved in human trafficking. Employing his unique set of skills forged in the fires of countless conflicts, he embarks on a dark path of vengeance. With the sole aim of rescuing Gabriela from her captors, Rambo must confront not only the cartel's vicious members but also the possibility of facing his own limits in a world he can no longer fully control. The rescue mission turns personal as he fights through an underground network of crime and violence, with each step fueling his relentless determination to protect the young woman he considers family.