During World War II, a group of young American bomber crewmen is stationed in England and assigned to the B-17 Flying Fortress. These men have already completed 24 dangerous missions over enemy territory and are on the cusp of finishing their 25th, a milestone that would grant them safe passage home. The camaraderie among the crew is tight-knit, as they have faced the hazards of war together, relying on each other to survive the harrowing raids. Among them, the captain, the bombardier, the navigator, and the rest of the team grapple with their fears, hopes, and the devastating implications of the war they witness from above.

As they prepare for their final mission, a highly dangerous bomb run over a heavily fortified target, tension mounts both within the crew and from the higher command, who are determined to make this mission count strategically. The young men must confront their inner anxieties and moral dilemmas while dealing with the immense physical threats posed by anti-aircraft fire, enemy fighter planes, and mechanical failures. In this intense atmosphere, their training and bonds are put to the ultimate test, drawing out acts of leadership, bravery, and sacrifice as they strive to complete their final flight and return home.