Adrienne Willis, a woman struggling with a recent separation from her husband and trying to manage her chaotic life, seeks refuge in a charming seaside inn in Rodanthe, North Carolina. She agrees to look after the inn for her friend for a weekend, hoping the solitude will help her reflect and find direction. At the same time, Dr. Paul Flanner, a surgeon haunted by a tragic incident, arrives at the inn facing his own emotional turmoil and seeking redemption. Both burdened by their pasts, Adrienne and Paul find themselves unexpectedly drawn to one another.

As they share their stories and support each other through their respective ordeals, a deep and transformative connection begins to form. The peaceful and picturesque setting of the coastal town serves as the backdrop of their unfolding relationship, offering them both comfort and the potential for new beginnings. Their weekend together becomes a pivotal juncture in their lives, paving the way for healing and change.