Greg, a socially awkward high school senior, navigates life by staying on the fringes and making bizarre film parodies with his co-worker, Earl. His life takes an unexpected turn when his mother insists that he spend time with Rachel, a classmate who has just been diagnosed with leukemia. Initially reluctant, Greg begins to form a genuine bond with Rachel as they confront her illness together. Amidst their budding friendship, Greg introduces Rachel to his film projects, and she soon becomes an integral part of their creative process.

Despite his initial detachment, Greg's connection with Rachel deepens, challenging him to face his own fears and insecurities. As Rachel's condition worsens, their friendship is tested, forcing Greg into uncharted emotional territory. Through their shared experiences, Greg learns important lessons about compassion, selflessness, and the true value of human connections. Their journey together leaves an indelible mark on both their lives, culminating in profound personal growth for Greg.