Toula Portokalos-Miller continues to navigate her busy life in Chicago, balancing responsibilities at her family’s Greek restaurant, raising teenage daughter Paris, and maintaining her marriage to Ian. Her extended, boisterous family remains involved in every aspect of her life, often overwhelming her with their constant interventions and traditional values. Meanwhile, Paris is preparing for college and struggling with her own identity amidst her family’s expectations. As she explores different university options, the tension between wanting to stay close to family and seeking independence becomes a focal point for both mother and daughter.

In the midst of handling these pressures, a shocking discovery about her parents' marriage adds another layer of chaos to Toula's life. This revelation sets off a chain of events that require the family to come together, leading to heartfelt moments, comedic mishaps, and a renewed sense of unity. The story dives into themes of familial bonds, cultural traditions, and personal growth as each member of the Portokalos clan learns to embrace change while maintaining their strong, supportive ties. Through the ups and downs, Toula learns to find balance in her relationships and rediscover the importance of family.