After coming out of self-imposed exile, extreme athlete and former government operative Xander Cage finds himself entangled in a deadly conspiracy that points to collusion at the highest levels of world governments. After a device known as Pandora's Box, which can control military satellites to crash as bombs, is stolen from the CIA's office, Cage is pulled back into the cloak-and-dagger world by his handler Augustus Gibbons. Despite the apparent death of his friend and boss, Cage moves forward with the mission, assembling a new team of thrill-seeking cohorts.

Xander's new team is eclectic and highly skilled, including sharpshooter Adele Wolff, DJ and parkour expert Nicks, and getaway driver Tennyson Torch. Meanwhile, the device lands in the hands of Xiang and his team, who are also formidable operatives with their own agendas. Xander finds himself at odds with these talented individuals while trying to retrieve the device. As they race to gain control of Pandora's Box before it can be used for catastrophic purposes, the group uncovers a conspiracy that runs deeper than they imagined, demanding they figure out who they can really trust.