In the once-booming home of pharmaceutical giant Umbrella Corporation, Raccoon City is now a dying Midwestern town. The company's exodus left the city a wasteland…with great evil brewing below the surface. When the malevolence is unleashed, the town's people are forever…changed…and a small group of survivors must work together to uncover the truth behind Umbrella and make it through the night.

Claire Redfield, a runaway who returns to Raccoon City to reconnect with her brother Chris, a rookie police officer, finds the town infested with terrifying creatures. Alongside other survivors, including officer Jill Valentine and Umbrella Corporation operative Albert Wesker, they must navigate through the chaos. As the group’s reality unravels, they discover the sinister nature of the corporation's experiments and its connection to the outbreak.