An unexpected family emergency forces Cindy and Bob Russell to leave their suburban Chicago home in a hurry. With no other immediate options, they reluctantly decide to call upon Bob's slovenly brother, Buck, to take care of their three kids while they're away. Buck, an unemployed slob who's more accustomed to a carefree, child-free lifestyle, suddenly finds himself in the position of acting guardian to his nieces and nephew: rebellious teenager Tia, awkward 12-year-old Miles, and the adorable, precocious 8-year-old Maizy.

Despite Buck's initial lack of parenting skills and his unconventional methods, he soon begins to charm his way into the children's lives with his good-hearted but bumbling attempts at caregiving. However, his biggest challenge comes in the form of Tia, who resists Buck's efforts to bond with her and his authority at every turn. As Buck struggles to navigate the complexities of keeping house and the dynamics of taking care of children with very different needs and personalities, he and the kids start to form an unlikely bond. Nonetheless, the situation teems with comedic mishaps and moments of heartfelt connection, showcasing an unorthodox approach to family caregiving and the unexpected journeys it can lead to.